1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.215
Position:
61593005
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-10.591
Reference Allele:
A
-log10(P):
-58.679
MAF:
0.346
Beta (Num):
-0.139
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects the activity of FADS1/FADS2, where higher activity leads to increased arachidonic acid (20:4) incorporation into phosphatidylethanolamines relative to oleic acid (18:1).1[1], 2[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, influenced by genetic variants, alters the balance of fatty acids, which is associated with dyslipidemia (hypercholesterolemia, altered triglycerides) and type 2 diabetes.10[1], 11[2], 12[3], 3[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data