1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)* to 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Denominator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Metabolite Accession: GCST90200063
Name: 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Hmdb Id: HMDB0008946
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPWUZHVZZKSTPV

Associated Genomic Regions

Region: rs174560

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.174
Position:
61581764
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
-12.938
Reference Allele:
T
-log10(P):
-86.488
MAF:
0.308
Beta (Num):
-0.144
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.030
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs9379992

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.114
Position:
10984330
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
9.136
Reference Allele:
G
-log10(P):
-44.182
MAF:
0.432
Beta (Num):
0.039
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.075
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, polyunsaturated fatty acid biosynthesis.6[1]

Ratio Explanation:

This ratio reflects the balance between omega-6 (arachidonic acid) and omega-3 (docosahexaenoic acid) containing phosphatidylethanolamines, modulated by FADS1 enzyme activity in PUFA synthesis.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters enzyme activity, impacting the balance of pro-inflammatory omega-6 and anti-inflammatory omega-3 fatty acids.1[1], 7[2], 8[3] This shift can influence lipid metabolism and inflammatory responses seen in asthma, dermatitis, and hypercholesterolemia.9[4], 10[5], 7[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data