1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)* to 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Metabolite Accession: GCST90200065
Name: 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Hmdb Id: HMDB0009012
Super Pathway: NA
Sub Pathway: NA
Inchikey: XYYHNDVKALDFHQ

Associated Genomic Regions

Region: rs3734398

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.116
Position:
10982973
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
8.142
Reference Allele:
T
-log10(P):
-35.483
MAF:
0.426
Beta (Num):
0.038
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.6[1], 7[2]

Ratio Explanation:

This ratio reflects the balance between glycerophosphoethanolamines containing omega-6 (arachidonic acid, 20:4) and omega-3 (DHA, 22:6) fatty acids, whose synthesis is modulated by ELOVL2.2[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

As no phenotype is provided, a causal link connecting ELOVL2, the ratio of 1-palmitoyl-2-arachidonoyl-gpe to 1-stearoyl-2-docosahexaenoyl-gpe, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data