1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)* to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Denominator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.409
Position:
61592362
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-19.252
Reference Allele:
A
-log10(P):
-188.506
MAF:
0.345
Beta (Num):
-0.140
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.269
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.6[1], 7[2]

Ratio Explanation:

The ratio of arachidonic acid (20:4)-containing PE to linolenic acid (18:3)-containing PC likely reflects the enzymatic efficiency of the FADS gene cluster.2[1], 6[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, reflected by the ratio. This change in lipid composition impacts systemic lipid levels and inflammatory responses, contributing to phenotypes like hypercholesterolemia, cholelithiasis, and asthma.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data