1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.243
Position:
61570783
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-13.396
Reference Allele:
T
-log10(P):
-92.558
MAF:
0.339
Beta (Num):
-0.114
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Ether lipid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lands cycle.5[1]

Ratio Explanation:

This ratio reflects FADS desaturase activity, comparing a plasmalogen with a monounsaturated fatty acid (18:1) to a lysophospholipid containing a precursor polyunsaturated fatty acid (18:2).1[1], 2[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters enzyme activity, which modifies the balance of polyunsaturated fatty acids.1[1], 6[2], 7[3] This dysregulation of fatty acid metabolism is linked to inflammatory responses and lipid profiles, contributing to phenotypes like inflammatory bowel disease, asthma, and hypercholesterolaemia.6[4], 8[5], 9[6], 10[7], 11[8], 12[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data