1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.397
Position:
61570783
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-19.240
Reference Allele:
T
-log10(P):
-188.279
MAF:
0.339
Beta (Num):
-0.114
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.10[1], 11[2]

Ratio Explanation:

The ratio reflects the balance between a choline plasmalogen and a lysophosphatidylethanolamine, lipids whose acyl chain composition is influenced by FADS desaturase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are associated with altered FADS activity, which impacts the balance of polyunsaturated fatty acids.2[1], 3[2], 5[3] This dysregulation affects the composition of various lipids, contributing to the altered ratio and is strongly linked to disorders like pure hypercholesterolaemia.12[4], 13[5], 14[6], 15[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data