1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Associated Genomic Regions

Region: rs102274

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.159
Position:
61557826
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
-14.358
Reference Allele:
T
-log10(P):
-105.977
MAF:
0.340
Beta (Num):
-0.115
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.044
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs4962237

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Clumped rQTL variant

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SNP Summary

Chr:
9
Beta (Ratio):
0.159
Position:
140358581
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
7.818
Reference Allele:
C
-log10(P):
-32.862
MAF:
0.072
Beta (Num):
0.105
Novel Locus:
Yes ✔️
SE (Num):
0.029
Beta (Den):
-0.054
SE (Den):
0.030
No CNV overlap
rQTL cluster:
177
Reaction Distance:
NA
Closest Genes:
PNPLA7 NSMF ENTPD8 NOXA1 EXD3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis6[1], 7[2]

Denominator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis8[1], 7[2]

Ratio Explanation:

The ratio reflects the balance of oleic acid (18:1) and linoleic acid (18:2) incorporation into plasmalogens, which is modulated by FADS1 desaturase activity.3[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 variants influence fatty acid desaturation, affecting the balance of oleoyl and linoleoyl lipids.3[1], 5[2] This altered lipid profile is strongly associated with hypercholesterolemia, a risk factor for cardiovascular diseases.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data