1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.346
Position:
61557803
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
-14.436
Reference Allele:
T
-log10(P):
-107.096
MAF:
0.346
Beta (Num):
-0.120
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.227
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and glycerophospholipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Phosphatidylethanolamine and glycerophospholipid metabolism.7[1], 6[2], 8[3]

Ratio Explanation:

The ratio reflects the relative activity of fatty acid desaturase enzymes (FADS1/FADS2), where altered activity impacts the balance of specific ether and ester phospholipids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS gene cluster alter FADS1/FADS2 activity, which modifies the balance of pro-inflammatory and pro-resolving lipid mediators, influencing susceptibility to inflammatory conditions like IBD and affecting cholesterol and lipoprotein levels, which are associated with valvular heart disease and cholelithiasis.3[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data