1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Structure of lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)*
Metabolite Accession: GCST90200098
Name: lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: MKOKWBRPIBQYJJ

Associated Genomic Regions

Region: rs1077989

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.126
Position:
67975822
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
-9.252
Reference Allele:
A
-log10(P):
-45.266
MAF:
0.476
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.029
SE (Den):
0.015
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 ARG2

Region: rs4147929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.375
Position:
1063443
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
21.207
Reference Allele:
G
-log10(P):
-228.147
MAF:
0.174
Beta (Num):
0.010
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.365
SE (Den):
0.020
No CNV overlap
rQTL cluster:
12
Reaction Distance:
NA
Closest Genes:
ABCA7 HMHA1 POLR2E CNN2 GPX4

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism

Denominator Metabolite Explanation:

Sphingolipid metabolism

Ratio Explanation:

An inverse relationship between a plasmalogen (ether phospholipid) and a glycosphingolipid, potentially reflecting a balance between membrane fluidity and signaling platforms, modulated by TMEM229B.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The TMEM229B gene, with eQTL colocalization and significant Mendelian Randomization, likely influences the balance between ether lipid and sphingolipid pathways. This altered lipid metabolism may affect red blood cell membrane composition and function, leading to changes in MCHC, RBC count, Hb, and MCV.

Phenotype Driver:

Gene-centric:TMEM229B

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data