1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)* to glycosyl ceramide (d18:2/24:1, d18:1/24:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Denominator Metabolite

Metabolite Accession: GCST90200118
Name: glycosyl ceramide (d18:2/24:1, d18:1/24:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1077989

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.123
Position:
67975822
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
-8.740
Reference Allele:
A
-log10(P):
-40.600
MAF:
0.476
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.026
SE (Den):
0.015
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 ARG2

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism, Glycosphingolipid biosynthesis.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

This ratio may reflect the balance between membrane glycerophospholipids and sphingolipids, potentially regulated by the flippase activity of ATP10D.1[1], 2[2], 3[3], 11[4], 12[5]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants near ATP10D and TMEM229B are associated with the ratio of plasmalogen to glycosyl ceramide, suggesting altered membrane lipid homeostasis. No phenotype link was provided.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data