1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.416
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-19.162
Reference Allele:
C
-log10(P):
-186.771
MAF:
0.338
Beta (Num):
-0.287
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Arachidonic acid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism

Ratio Explanation:

The ratio reflects the balance between ether-linked and ester-linked glycerophospholipids, influenced by FADS1/FADS2 activity on polyunsaturated fatty acid precursors like linoleic acid.1[1], 2[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants influence the levels of polyunsaturated fatty acids.4[1], 5[2] This altered lipid profile is associated with a range of inflammatory and metabolic disorders including benign and malignant neoplasms of the colon, valvular heart disease, IBD, and type 2 diabetes, likely through modulation of inflammatory pathways.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data