1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.571
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-24.344
Reference Allele:
C
-log10(P):
-299.743
MAF:
0.338
Beta (Num):
-0.287
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and glycerophospholipid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid degradation.6[1]

Ratio Explanation:

The ratio reflects the relative abundance of a plasmalogen containing arachidonic acid to a lysophosphatidylethanolamine, influenced by FADS1/FADS2-mediated PUFA metabolism.7[1], 8[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1 and FADS2 alter the balance of PUFAs, affecting the levels of these two ether- and lysophospholipids. This imbalance is associated with altered lipid metabolism and an increased risk for hypercholesterolemia and other inflammatory and cardiovascular conditions.7[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data