1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Metabolite Accession: GCST90200061
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpe (p-16:0/18:1)*
Hmdb Id: HMDB0011342
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZVVYJAAMWXATNY

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.342
Position:
61569830
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-22.500
Reference Allele:
C
-log10(P):
-256.456
MAF:
0.338
Beta (Num):
-0.287
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.054
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis

Denominator Metabolite Explanation:

Plasmalogen biosynthesis

Ratio Explanation:

The ratio reflects the relative activity of fatty acid desaturase enzymes, where a higher ratio suggests increased production of arachidonic acid (20:4) relative to oleic acid (18:1).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, influenced by genetic factors, impacts the balance of pro-inflammatory and anti-inflammatory fatty acids, contributing to the risk of inflammatory conditions like valvular heart disease and asthma.4[1], 5[2], 6[3], 7[4], 8[5], 9[6], 10[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data