1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.524
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-22.604
Reference Allele:
C
-log10(P):
-258.824
MAF:
0.338
Beta (Num):
-0.287
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.237
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis, Arachidonic acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate/Linolenate metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity, where higher activity results in more arachidonic acid (numerator) produced from precursors like linoleic acid (denominator).8[1], 9[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter desaturase activity, affecting the balance of pro- and anti-inflammatory polyunsaturated fatty acids.8[1], 10[2], 11[3] This dysregulation of lipid metabolism is linked to various inflammatory, cardiovascular (hypercholesterolemia, valvular disease), and metabolic (Type 2 diabetes) phenotypes.12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data