1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)* to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.445
Position:
61581764
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-19.468
Reference Allele:
T
-log10(P):
-192.703
MAF:
0.307
Beta (Num):
-0.290
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid and carnitine metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects fatty acid desaturation activity, where FADS1 and FADS2 convert precursors like dihomo-linolenic acid into longer-chain polyunsaturated fatty acids like arachidonic acid.1[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, is linked to altered lipid profiles and an increased risk for inflammatory conditions like asthma and disorders of lipoprotein metabolism due to inefficient long-chain polyunsaturated fatty acid synthesis.10[1], 9[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data