behenoyl dihydrosphingomyelin (d18:0/22:0)* to sphingomyelin (d18:1/19:0, d19:1/18:0)*

Numerator Metabolite

Structure of behenoyl dihydrosphingomyelin (d18:0/22:0)*
Metabolite Accession: GCST90200059
Name: behenoyl dihydrosphingomyelin (d18:0/22:0)*
Hmdb Id: HMDB0012091
Super Pathway: NA
Sub Pathway: NA
Inchikey: FONAXCRWZQFJHY

Denominator Metabolite

Metabolite Accession: GCST90200131
Name: sphingomyelin (d18:1/19:0, d19:1/18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs17101394

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
14
Beta (Ratio):
-0.349
Position:
64232386
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
-14.436
Reference Allele:
G
-log10(P):
-107.106
MAF:
0.164
Beta (Num):
-0.098
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.251
SE (Den):
0.019
No CNV overlap
rQTL cluster:
47
Reaction Distance:
NA
Closest Genes:
SGPP1 SYNE2 WDR89 PPP2R5E ESR2

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Sphingolipid biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio may reflect the balance between a saturated sphingolipid precursor (dihydrosphingomyelin) and a final unsaturated product (sphingomyelin), potentially indicating altered desaturase activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SGPP1 function likely disrupts sphingolipid metabolism, including the balance of ceramides and sphingomyelins, which is linked to insulin resistance (HbA1c) and dyslipidemia (Triglycerides).8[1], 9[2]

Phenotype Driver:

Gene-centric:SGPP1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data