1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.217
Position:
116648917
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
-7.887
Reference Allele:
C
-log10(P):
-33.412
MAF:
0.131
Beta (Num):
-0.117
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.101
SE (Den):
0.023
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, Plasmalogen biosynthesis.2[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.3[1]

Ratio Explanation:

The ratio of a plasmalogen to a lysophospholipid may reflect alterations in lipoprotein composition and turnover, influenced by APOA5 gene function.1[1], 4[2], 5[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the APOA5 gene cluster alters lipoprotein metabolism, a change reflected in the lipid ratio.6[1], 7[2] This dysregulation of lipid transport is a primary mechanism for developing associated phenotypes like hypercholesterolemia, coronary artery disease, and myocardial infarction.1[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data