1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.225
Position:
116648917
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-8.210
Reference Allele:
C
-log10(P):
-36.047
MAF:
0.131
Beta (Num):
-0.117
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.108
SE (Den):
0.022
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Plasmalogen metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Phosphatidylinositol metabolism, Glycerophospholipid metabolism.3[1], 5[2], 6[3]

Ratio Explanation:

The ratio reflects the balance between a choline-containing plasmalogen and a phosphatidylinositol, both involved in lipid signaling and membrane structure, influenced by apolipoprotein A5.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in APOA5 influence its function in regulating triglyceride and lipoprotein metabolism.7[1], 8[2], 2[3] This altered lipid metabolism, reflected in the plasmalogen to phosphatidylinositol ratio, contributes to phenotypes like hypercholesterolemia and coronary artery disease, which are strongly associated with dyslipidemia.9[4]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data