1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.433
Position:
61569830
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-21.686
Reference Allele:
C
-log10(P):
-238.441
MAF:
0.338
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, GPI-anchor biosynthesis.

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 desaturases, indicating the conversion rate of linoleic acid (18:2) found in GPE to arachidonic acid (20:4) in GPI.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 alter the balance of pro- and anti-inflammatory fatty acids, impacting lipid profiles. This dysregulation is linked to metabolic phenotypes like pure hypercholesterolemia and cholelithiasis, where altered cholesterol and lipid metabolism are key pathological features.4[1], 5[2], 6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data