1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to 1-palmitoyl-gpi (16:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Structure of 1-palmitoyl-gpi (16:0)
Metabolite Accession: GCST90199810
Name: 1-palmitoyl-gpi (16:0)
Hmdb Id: HMDB0061695
Super Pathway: NA
Sub Pathway: NA
Inchikey: UOXRPRZMAROFPH

Associated Genomic Regions

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.144
Position:
54677189
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-8.771
Reference Allele:
C
-log10(P):
-40.874
MAF:
0.435
Beta (Num):
-0.073
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.072
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects the MBOAT7-driven acylation of 1-palmitoyl-GPI to form 1-palmitoyl-2-arachidonoyl-GPI, a key step in remodeling GPI anchors with arachidonic acid.5[1], 11[2], 12[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 activity, potentially influenced by genetic factors, can lead to lower levels of arachidonoyl-containing GPIs, which may alter lipid metabolism and increase the risk for cholelithiasis and other metabolic disorders.13[1], 14[2], 15[3]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data