1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs174546

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.358
Position:
61569830
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-19.678
Reference Allele:
C
-log10(P):
-196.817
MAF:
0.338
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.208
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs8736

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.282
Position:
54677189
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-15.920
Reference Allele:
C
-log10(P):
-129.716
MAF:
0.435
Beta (Num):
-0.073
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.210
SE (Den):
0.015
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Fatty acid biosynthesis6[1], 7[2]

Denominator Metabolite Explanation:

Glycerophosphoinositol metabolism, Fatty acid biosynthesis6[1], 8[2]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 enzymes, which catalyze the conversion of linoleic acid (18:2) precursors to arachidonic acid (20:4) for incorporation into GPI lipids.3[1], 4[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected by the GPI ratio, dysregulates the balance of inflammatory lipid mediators derived from arachidonic acid, contributing to inflammatory conditions like cholelithiasis and metabolic phenotypes such as pure hypercholesterolemia, for which there is significant Mendelian Randomization evidence.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data