1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.386
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-18.003
Reference Allele:
C
-log10(P):
-165.181
MAF:
0.338
Beta (Num):
-0.149
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.237
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism

Denominator Metabolite Explanation:

Glycerophosphocholine metabolism

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase efficiency, comparing the product 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4) to a substrate-containing phospholipid, 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Increased FADS gene activity, indicated by a higher ratio, alters the balance of polyunsaturated fatty acids. This dysregulates lipid metabolism and inflammatory responses, plausibly contributing to pure hypercholesterolaemia and inflammatory skin conditions like follicular cysts.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data