1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.317
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-14.870
Reference Allele:
T
-log10(P):
-113.489
MAF:
0.307
Beta (Num):
-0.162
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.155
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylinositol synthesis, glycerophospholipid metabolism5[1], 6[2], 7[3], 8[4], 9[5]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio reflects the activity of FADS1/FADS2, where lower activity leads to decreased synthesis of arachidonic acid (a component of the numerator) and accumulation of its precursors, including the denominator's fatty acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity alters the balance of polyunsaturated fatty acids, which can impact inflammatory processes and the skin barrier, contributing to seborrhoeic dermatitis.14[1], 15[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data