1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)* to 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)

Numerator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Metabolite Accession: GCST90200692
Name: 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Hmdb Id: HMDB0007982
Super Pathway: NA
Sub Pathway: NA
Inchikey: IIZPXYDJLKNOIY

Associated Genomic Regions

Region: rs626283

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.141
Position:
54677001
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-7.906
Reference Allele:
G
-log10(P):
-33.560
MAF:
0.438
Beta (Num):
-0.074
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.067
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
TMC4 MBOAT7 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylinositol biosynthesis.2[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.2[1]

Ratio Explanation:

The ratio reflects MBOAT7 activity; reduced function decreases 1-palmitoyl-2-arachidonoyl-gpi synthesis from its precursor, altering the balance between these two related phospholipid species.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 function alters phosphatidylinositol metabolism, which may impact platelet and alkaline phosphatase levels, though the direct mechanism linking the specific ratio to these phenotypes is not fully established.4[1], 5[2], 6[3]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data