1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)* to 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Metabolite Accession: GCST90200063
Name: 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Hmdb Id: HMDB0008946
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPWUZHVZZKSTPV

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Metabolite Accession: GCST90200065
Name: 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Hmdb Id: HMDB0009012
Super Pathway: NA
Sub Pathway: NA
Inchikey: XYYHNDVKALDFHQ

Associated Genomic Regions

Region: rs174553

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.098
Position:
61575158
SE (Ratio):
0.007
Effect Allele:
G
Z-score (Ratio):
13.901
Reference Allele:
A
-log10(P):
-99.486
MAF:
0.338
Beta (Num):
0.028
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.071
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.3[1], 5[2]

Ratio Explanation:

The ratio reflects the relative incorporation of palmitic acid (16:0) versus stearic acid (18:0) into phosphatidylethanolamines, influenced by overall fatty acid pool dynamics.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, which affects the composition of phospholipids like PE.6[1], 7[2] This dysregulation is linked to inflammatory and metabolic phenotypes including dyslipidemia, type 2 diabetes, and cholelithiasis through modulation of lipid mediators and membrane composition.8[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data