1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.454
Position:
61588305
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
24.904
Reference Allele:
A
-log10(P):
-313.542
MAF:
0.344
Beta (Num):
0.207
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.246
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs8736

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.384
Position:
54677189
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
21.459
Reference Allele:
C
-log10(P):
-233.544
MAF:
0.436
Beta (Num):
0.210
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol biosynthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Glycerophosphoinositol biosynthesis, Fatty acid desaturation.7[1], 8[2], 10[3]

Ratio Explanation:

This ratio reflects the efficiency of converting linoleoyl-containing GPIs to arachidonoyl-containing GPIs, a process mediated by the FADS enzymes that desaturate fatty acids.11[1], 12[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in `FADS` genes alter fatty acid desaturation, affecting the balance of pro-inflammatory (arachidonic acid-derived) and anti-inflammatory lipids.13[1], 14[2] This dysregulation is linked to inflammatory conditions like cholelithiasis, type 2 diabetes, and inflammatory bowel disease.15[3], 16[4], 17[5], 18[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data