1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to stearidonate (18:4n3)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.329
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
15.539
Reference Allele:
C
-log10(P):
-123.699
MAF:
0.340
Beta (Num):
0.208
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.121
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

The ratio reflects FADS2 activity, which synthesizes the denominator (stearidonate) from ALA and also metabolizes linoleic acid, a component of the numerator.3[1], 4[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS2 gene function modifies the balance of omega-6 and omega-3 fatty acids, which are precursors to inflammatory mediators.6[1], 7[2] This imbalance is linked to inflammatory (IBD, asthma) and metabolic (T2D, hypercholesterolemia) diseases through its influence on lipid metabolism and inflammation.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data