1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to 1-palmitoyl-gpc (16:0)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.272
Position:
61551927
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
14.988
Reference Allele:
A
-log10(P):
-115.250
MAF:
0.342
Beta (Num):
0.204
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.068
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1]

Ratio Explanation:

The ratio reflects polyunsaturated fatty acid (PUFA) synthesis activity by FADS enzymes, contrasting a PUFA-containing lipid (numerator) with a lysophospholipid containing a saturated fatty acid (denominator).3[1], 7[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid levels, reflected by the ratio.3[1], 7[2], 8[3] This dysregulation is linked to inflammatory conditions and altered lipid metabolism, such as asthma, hypercholesterolemia, and cholelithiasis, which are associated with PUFA balance.2[4], 9[5], 5[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data