1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.478
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
21.424
Reference Allele:
A
-log10(P):
-232.780
MAF:
0.344
Beta (Num):
0.207
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Triacylglycerol biosynthesis.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Endocannabinoid signaling pathway.9[1], 10[2], 11[3], 12[4], 13[5]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid synthesis and endocannabinoid production, influenced by FADS1/FADS2 activity on fatty acid precursors.14[1], 15[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids, impacting conditions like inflammatory bowel disease and type 2 diabetes.16[1], 17[2], 18[3], 19[4], 20[5], 21[6], 22[7], 23[8], 24[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data