1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to 1-arachidonoyl-gpe (20:4n6)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.578
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
26.619
Reference Allele:
A
-log10(P):
-357.807
MAF:
0.344
Beta (Num):
0.207
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.370
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism8[1], 9[2]

Ratio Explanation:

The ratio reflects the conversion of linoleic acid to arachidonic acid, where lower FADS1/FADS2 activity is associated with higher substrate and lower product.4[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an increased ratio, alters fatty acid pools, impacting inflammatory processes and increasing risk for cholelithiasis and metabolic disorders.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data