1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.534
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
24.728
Reference Allele:
A
-log10(P):
-309.177
MAF:
0.344
Beta (Num):
0.207
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.327
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism5[1]

Ratio Explanation:

The ratio reflects the conversion of linoleic acid to arachidonic acid, where higher FADS activity leads to more denominator, and lower activity increases the numerator.1[1], 2[2], 3[3], 4[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, influenced by genetic variants, alters fatty acid metabolism, leading to imbalances in pro-inflammatory and anti-inflammatory lipid mediators.7[1], 8[2], 9[3] This dysregulation is linked to inflammatory conditions like inflammatory bowel disease and metabolic traits such as cholelithiasis.10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data