1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to sphingomyelin (d18:2/24:2)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of sphingomyelin (d18:2/24:2)*
Metabolite Accession: GCST90200124
Name: sphingomyelin (d18:2/24:2)*
Hmdb Id: HMDB0240644
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAWJSGKLPKMOGG

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.221
Position:
116648917
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
8.052
Reference Allele:
C
-log10(P):
-34.740
MAF:
0.131
Beta (Num):
0.108
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.113
SE (Den):
0.021
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism.9[1], 6[2], 10[3]

Ratio Explanation:

This ratio reflects the balance between glycerophospholipid and sphingolipid pools, which is influenced by apolipoprotein-mediated lipid transport.11[1], 12[2], 13[3], 14[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in the APOA1/A4/A5/C3 gene cluster alter apolipoprotein levels, affecting the transport of glycerophospholipids and sphingolipids.11[1], 15[2], 12[3], 13[4] This dysregulation is linked to altered lipid ratios and a higher risk of atherosclerosis and heart disease.16[5], 14[6], 17[7], 10[8]

Phenotype Driver:

Gene-centric:APOA1/A4/A5/C3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data