1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.282
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
14.931
Reference Allele:
T
-log10(P):
-114.395
MAF:
0.347
Beta (Num):
0.203
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.079
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Sphingolipid metabolism6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid and sphingolipid synthesis, potentially influenced by FADS1/FADS2-mediated fatty acid availability for their respective biosynthetic pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter fatty acid desaturation, affecting the composition of glycerophospholipids and sphingolipids.9[1], 10[2], 11[3] This dysregulation is associated with an increased risk for inflammatory conditions, hypercholesterolemia, and cholelithiasis.12[4], 5[5], 10[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data