1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to sphingomyelin (d18:2/21:0, d16:2/23:0)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Metabolite Accession: GCST90200129
Name: sphingomyelin (d18:2/21:0, d16:2/23:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.290
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
14.951
Reference Allele:
T
-log10(P):
-114.700
MAF:
0.347
Beta (Num):
0.203
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.087
SE (Den):
0.013
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism.6[1], 7[2], 8[3], 9[4]

Ratio Explanation:

This ratio reflects the balance between glycerophospholipid and sphingolipid synthesis, influenced by FADS-mediated polyunsaturated fatty acid metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid levels, impacting the balance of pro-inflammatory and pro-resolving lipid mediators.10[1], 11[2] This dysregulation is linked to inflammatory and metabolic phenotypes like IBD, asthma, type 2 diabetes, and hypercholesterolemia.1[3], 12[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data