1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to cerotoylcarnitine (c26)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of cerotoylcarnitine (c26)*
Metabolite Accession: GCST90200136
Name: cerotoylcarnitine (c26)*
Hmdb Id: HMDB0006347
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOCKWDDTAHPJSX

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.281
Position:
61569830
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
15.156
Reference Allele:
C
-log10(P):
-117.802
MAF:
0.340
Beta (Num):
0.208
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol (GPI)-anchor biosynthesis, Fatty acid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid transport, Peroxisomal very long-chain fatty acid beta-oxidation.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio reflects FADS-mediated desaturation of fatty acids for GPI anchor synthesis versus transport of very-long-chain fatty acids for mitochondrial oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variation influences fatty acid composition, affecting glycerophosphoinositol synthesis and potentially contributing to dyslipidemia, cholelithiasis, and type 2 diabetes by altering membrane composition and lipid signaling.12[1], 13[2], 14[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data