1-stearoyl-2-linoleoyl-gpi (18:0/18:2) to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.399
Position:
61569830
SE (Ratio):
0.027
Effect Allele:
T
Z-score (Ratio):
14.844
Reference Allele:
C
-log10(P):
-113.105
MAF:
0.340
Beta (Num):
0.208
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.190
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, where higher activity leads to increased docosatrienoate (22:3n6) production from linoleic acid, a component of 1-stearoyl-2-linoleoyl-gpi.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, is associated with altered lipid profiles and a higher incidence of inflammatory conditions and metabolic disorders like type 2 diabetes and cholelithiasis, due to its impact on the balance of pro- and anti-inflammatory lipid mediators.13[1], 14[2], 15[3], 16[4], 17[5], 18[6], 19[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data