1,2-dilinoleoyl-gpe (18:2/18:2)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.476
Position:
61557803
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
20.577
Reference Allele:
T
-log10(P):
-214.956
MAF:
0.370
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.249
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Arachidonic acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase activity, comparing a glycerophospholipid containing the precursor linoleic acid (18:2) to one with the product arachidonic acid (20:4).10[1], 11[2], 12[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, affecting the balance of pro-inflammatory arachidonic acid (20:4) and its precursors.12[1], 13[2], 14[3] This dysregulation of fatty acid metabolism plausibly contributes to inflammatory conditions like asthma, IBD, and metabolic phenotypes like cholelithiasis and dyslipidemia.15[4], 16[5], 17[6], 18[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data