1,2-dilinoleoyl-gpe (18:2/18:2)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.327
Position:
61579463
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
14.849
Reference Allele:
A
-log10(P):
-113.172
MAF:
0.361
Beta (Num):
0.231
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.096
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.10[1]

Denominator Metabolite Explanation:

Lysophospholipid metabolism.11[1], 12[2]

Ratio Explanation:

The ratio reflects the balance between a glycerophosphoethanolamine and a lysophosphatidylcholine, influenced by FADS enzymes that control fatty acid composition of these lipids.1[1], 2[2], 13[3], 14[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the eQTL colocalization, likely modifies the fatty acid composition of phospholipids, impacting inflammatory pathways and lipoprotein metabolism, which contributes to the diverse associated inflammatory, cardiovascular, and metabolic phenotypes.15[1], 3[2], 16[3], 17[4], 18[5], 9[6], 19[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data