1,2-dilinoleoyl-gpe (18:2/18:2)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.498
Position:
61588305
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
20.217
Reference Allele:
A
-log10(P):
-207.589
MAF:
0.367
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Alpha-Linolenic acid metabolism.3[1]

Denominator Metabolite Explanation:

Endocannabinoid signaling pathway.4[1], 5[2]

Ratio Explanation:

This ratio may reflect the enzymatic activity of FADS1/FADS2, where higher activity favors the synthesis of arachidonic acid, a precursor for 1-arachidonylglycerol.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity is associated with lower arachidonic acid levels, potentially impacting inflammatory processes and lipid profiles, which could contribute to the development of pure hypercholesterolemia.2[1], 6[2], 7[3] The ratio is also linked to valvular heart disease and IBD.1[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data