1,2-dilinoleoyl-gpe (18:2/18:2)* to 1-arachidonoyl-gpe (20:4n6)*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Denominator Metabolite

Structure of 1-arachidonoyl-gpe (20:4n6)*
Metabolite Accession: GCST90199791
Name: 1-arachidonoyl-gpe (20:4n6)*
Hmdb Id: HMDB0011517
Super Pathway: NA
Sub Pathway: NA
Inchikey: ROPRRXYVXLDXQO

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.599
Position:
61557803
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
25.717
Reference Allele:
T
-log10(P):
-334.160
MAF:
0.370
Beta (Num):
0.227
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.372
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity; a higher value suggests lower conversion of precursor linoleic acid (18:2) into downstream arachidonic acid (20:4).1[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters this ratio, dysregulating pro-inflammatory arachidonic acid levels.7[1], 8[2] This impacts lipid metabolism and inflammation, contributing to phenotypes like asthma, inflammatory bowel disease, pure hypercholesterolaemia, and cholelithiasis, which are observed in the associated phenotypes.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data