1,2-dilinoleoyl-gpe (18:2/18:2)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.500
Position:
61579463
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
19.758
Reference Allele:
A
-log10(P):
-198.406
MAF:
0.361
Beta (Num):
0.231
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.269
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid synthesis and fatty acid beta-oxidation, regulated by FADS enzymes which influence polyunsaturated fatty acid availability.4[1], 5[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturation, affecting the balance of pro-inflammatory and anti-inflammatory lipids, which contributes to the risk of inflammatory conditions like IBD, valvular heart disease, and metabolic disorders such as type 2 diabetes.6[1], 7[2], 8[3], 9[4], 10[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data