phenylacetylglutamate to xanthurenate

Numerator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.270
Position:
25794431
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
11.418
Reference Allele:
G
-log10(P):
-67.856
MAF:
0.460
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism6[1], 7[2]

Denominator Metabolite Explanation:

Tryptophan metabolism8[1], 9[2]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing the balance of unrelated gut-derived (phenylacetylglutamate) and tryptophan-derived (xanthurenate) metabolites.6[1], 8[2], 4[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant could alter its transport of urate and thyroid hormones, leading to downstream effects on uric acid levels and hematological indices.4[1], 10[2], 11[3], 12[4] Thyroid hormone dysregulation is known to affect red blood cell parameters, providing a plausible link to the observed phenotypes.12[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data