phenylacetylglutamate to n-acetylhistidine

Numerator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Denominator Metabolite

Structure of n-acetylhistidine
Metabolite Accession: GCST90199735
Name: n-acetylhistidine
Hmdb Id: HMDB0032055
Super Pathway: NA
Sub Pathway: NA
Inchikey: KBOJOGQFRVVWBH

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.254
Position:
25794431
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
11.556
Reference Allele:
G
-log10(P):
-69.452
MAF:
0.460
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.093
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism, gut microbiome.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Histidine metabolism.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio may reflect the balance between microbial metabolism of phenylalanine and host metabolism of histidine, potentially influenced by the transporter activity of SLC17A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant may alter the transport of substrates like urate, impacting renal function as suggested by the association with serum creatinine and uric acid.1[1], 2[2] This could indirectly influence the excretion of phenylacetylglutamate and N-acetylhistidine, linking to the observed hematological phenotypes.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data