phenylacetylglutamate to n-acetylphenylalanine

Numerator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Denominator Metabolite

Structure of n-acetylphenylalanine
Metabolite Accession: GCST90200677
Name: n-acetylphenylalanine
Hmdb Id: HMDB0000512
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBQJSKKFNMDLON

Associated Genomic Regions

Region: rs59569607;rs1937130

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.311
Position:
25787554
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
13.884
Reference Allele:
T
-log10(P):
-99.239
MAF:
0.444
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.146
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phenylalanine metabolism, Gut microbiota metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Phenylalanine metabolism.9[1], 10[2]

Ratio Explanation:

The ratio may reflect altered phenylalanine metabolism and transport, as both metabolites derive from phenylalanine and SLC17A4 transports various organic anions.11[1], 12[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC17A4 function could alter the transport of organic anions, including urate, directly linking to the uric acid phenotype.3[1], 13[2], 14[3], 15[4] The hematological phenotypes (MCH, MCV, MCHC, Hb) may be secondary to broader systemic effects of altered transport activity.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data