1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.231
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-11.474
Reference Allele:
T
-log10(P):
-68.502
MAF:
0.346
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.121
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis.8[1], 9[2], 10[3], 11[4], 12[5]

Denominator Metabolite Explanation:

Lysophospholipid metabolism.13[1], 14[2], 15[3], 16[4], 17[5], 18[6]

Ratio Explanation:

The ratio reflects the balance between plasmalogen synthesis and the bioavailability of linoleoyl-GPC, which is influenced by FADS1/FADS2 activity on its precursor, linoleic acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants influence PUFA metabolism, impacting levels of precursors for eicosanoids and endocannabinoids.5[1], 7[2] This altered lipid signaling is linked to a higher risk for dyslipidemia, cardiovascular diseases, and inflammatory conditions like asthma and inflammatory bowel disease.19[3], 20[4], 21[5], 22[6], 23[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data