1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.203
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-15.922
Reference Allele:
G
-log10(P):
-129.747
MAF:
0.176
Beta (Num):
-0.171
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.032
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs72719193

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.231
Position:
67969108
SE (Ratio):
0.010
Effect Allele:
A
Z-score (Ratio):
-24.146
Reference Allele:
G
-log10(P):
-294.916
MAF:
0.478
Beta (Num):
-0.327
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.096
SE (Den):
0.015
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 EIF2S1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen and glycerophospholipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Plasmalogen and glycerophospholipid metabolism.3[1], 4[2]

Ratio Explanation:

The ratio reflects the activity of fatty acid desaturases and elongases, with SCD influencing the balance between palmitoleate (16:1) and oleate (18:1) containing plasmalogens.1[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

SCD gene variants alter the ratio of 16:1 to 18:1 fatty acids within plasmalogens.1[1], 5[2] This shift in lipid composition can impact membrane function and signaling, plausibly contributing to the development of cardiovascular phenotypes like myocardial infarction and hypertension.6[3], 7[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data