1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Metabolite Accession: GCST90200060
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpc (p-16:0/18:2)*
Hmdb Id: HMDB0011211
Super Pathway: NA
Sub Pathway: NA
Inchikey: QLEHHUPUHJPURI

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.217
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-11.948
Reference Allele:
G
-log10(P):
-74.093
MAF:
0.176
Beta (Num):
-0.171
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.046
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs102275

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.148
Position:
61557803
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-10.112
Reference Allele:
T
-log10(P):
-53.679
MAF:
0.346
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.037
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen synthesis, fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen synthesis, PUFA metabolism4[1], 6[2]

Ratio Explanation:

This ratio reflects desaturase activity (FADS1/FADS2), contrasting plasmalogens with endogenously synthesized palmitoleate (16:1) against those with the essential fatty acid linoleate (18:2).7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters desaturase activity, affecting fatty acid pools for lipid synthesis.2[1], 7[2] This dysregulation contributes to lipoprotein disorders, hypercholesterolemia, and atherosclerosis, all of which are listed as associated phenotypes.9[3], 1[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data