1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Structure of 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Metabolite Accession: GCST90200067
Name: 1-stearoyl-2-linoleoyl-gpi (18:0/18:2)
Hmdb Id: HMDB0009809
Super Pathway: NA
Sub Pathway: NA
Inchikey: KZVRAFHIKMDULK

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.313
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-14.910
Reference Allele:
T
-log10(P):
-114.080
MAF:
0.346
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.203
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phosphatidylinositol metabolism, glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS1/FADS2 activity, comparing a plasmalogen (p-16:0/16:1) to a phosphatidylinositol containing linoleic acid (18:2), a FADS2 substrate.2[1], 8[2], 9[3], 4[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters fatty acid desaturation, reflected by the ratio. This dysregulates lipid metabolism and inflammatory pathways, contributing to phenotypes like hypercholesterolemia, cholelithiasis, and inflammatory conditions such as asthma and inflammatory bowel disease.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data