1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Metabolite Accession: GCST90200075
Name: 1-(1-enyl-palmitoyl)-2-linoleoyl-gpe (p-16:0/18:2)*
Hmdb Id: HMDB0011343
Super Pathway: NA
Sub Pathway: NA
Inchikey: LJVXDBWIBQQKFU

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.276
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-13.306
Reference Allele:
T
-log10(P):
-91.348
MAF:
0.346
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.165
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

This ratio compares a glycerolphosphocholine to a glycerolphosphoethanolamine with different fatty acids (16:1 vs 18:2), likely reflecting FADS activity on fatty acid availability.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid levels, impacting the composition of plasmalogens.2[1], 8[2], 9[3] This lipid dysregulation is a known risk factor for associated phenotypes like cholelithiasis, type 2 diabetes, and cardiovascular diseases.10[4], 11[5], 12[6], 13[7], 14[8], 15[9]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data