1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)* to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.238
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
-11.574
Reference Allele:
A
-log10(P):
-69.656
MAF:
0.344
Beta (Num):
-0.107
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.131
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs964184

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.230
Position:
116648917
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
-7.917
Reference Allele:
C
-log10(P):
-33.647
MAF:
0.131
Beta (Num):
-0.103
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
0.127
SE (Den):
0.023
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis; Ether lipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phosphatidylinositol biosynthesis; Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

This ratio reflects FADS1/FADS2 activity, contrasting a plasmalogen with a phosphatidylinositol, which indicates a shift in the underlying fatty acid pools available for complex lipid synthesis.8[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster alters desaturase activity, which changes fatty acid balances and the resulting composition of complex lipids like plasmalogens and phosphatidylinositols. This dysregulation contributes to the cardiometabolic and inflammatory phenotypes observed, including cholelithiasis and ischaemic heart disease.9[1], 10[2], 8[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data